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KMID : 1001920040350010023
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Journal of Korean Neurosurgical Society
2004 Volume.35 No. 1 p.23 ~ p.28
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Changes of Muscle Related Enzymes after Posterior Approaches to the Lumbar Spine
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Kang Joong-Sik
Lee Yong-Keun
Cho Joon
Moon Chang-Taek
Chang Sang-Keun
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Abstract
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bjective : Creatine phosphokinase-MM(CPK-MM) and lactate dehydrogenase(LDH) are well known indices of muscular injury. To know the degree of muscular injury during spinal surgery, the author report serial measurement of serum CPK-MM and LDH4 level.
Methods :The authors investigated 23 patients who underwent lumbar spinal surgery without bone fusion or instrumentation. Peripheral venous blood samples were serially collected 1 day before surgery, operation day, postoperative 3rd, 7th, 14th and 28th day. Postoperative back pain was measured by visual analogue scale. We evaluated the relatiorship between number of operation level, serial changes of serum CPK-MM, LDH4, duration of surgery and postoperative back pain.
Results : CPK-MM activity was higher after surgery than before it and reached at maximal level on the postoperative 3rd day, and it was returned to normal level on the postoperative 7th day. The score of postoperative back pain scale was ´:he highest on the postoperative 3rd day. CPK-MM activity was significantly correlated with operation level, duration of surgery, and postoperative back pain(P<0.05). In contrast, serum level of LDH4 showed no significant correlation with duration of surgery(P>0.05).
Conclusion : Postoperative muscle injury is inevitable in all patient who underwent spinal surgery, and these injuries are related extent of exposure and duration of surgery. To reduce muscle injury and postoperative back pain, less invasive and shorter surgery in time is recommend.
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KEYWORD
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Creatine phosphokinase MM, lactate dehydrogenase, Postoperative back pain
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